myristica fragrans chemical composition

The fruit contains a hard pit, which is nutmeg, while fleshy or net like outgrowth surrounding seeds and attached to the base of the seed which is called mace. Join ResearchGate to find the people and research you need to help your work. Myristica fragrans is native to the exotic Spice Islands or Maluku of Indonesia, though it now also grown in India, Malaysia, Sri Lanka, Taiwan, China, and the Caribbean region, amongst other countries. RESULTS: Thirty‐eight compounds in nutmeg oil and six compounds in mengkudu oil were identified by gas chromatography–mass spectrometry. and oral administration, respectively. Filho RB, Frota LMF, Gottlieb OR. USA.gov. Also, α-terpinyl acetate (34.55%), eucalyptol (24.91%), (-)-terpinen-4-ol (10.63%), linalool (7.69%) and neryl butyrate (6.58%) compounds identified in cardamom essential oil as major compounds. Direct characterization of nutmeg constituents by mass spectrometry. was studied against seizures induced by maximum electroshock (MES), pentylenetetrazol (PTZ), picrotoxin, and lithium sulphate-pilocarpine nitrate (Li-Pilo). is a large, leafy evergreen plant originating from Moluccas (the Spice Islands) and now cultivated in the West Indies. Among them, 1 (EC50 1.6 μM), 6 (1.5 μM), and 8 (1.4 μM) showed relatively strong activities, which were comparable to that of a synthetic CCR3 selective antagonist, SB328437 (0.78 μM). Antimicrobial activity of, Tommy I, Shiming L, Knut L. 1998. is a large, leafy evergreen plant originating from Moluccas (the Spice Islands) and now cultivated in the West Indies. Neolignans of, Barata LES, Santos LS, Ferri PH, Phillipson JD, Paine A, Croft SL. The yield of their composition of extracts and essential oils differs due to different methodologies. Methods: The anticonvulsant activity of MF (10, 30, 100 mg/kg i.p.) The structures of the compounds were identified by employing various spectroscopic methods. BACKGROUND: In this study the chemical composition, antioxidant activities and cytotoxic effect of the essential oils of Myristica fragrans (nutmeg) and Morinda citrifolia (mengkudu) were determined. This article presents comprehensive analyzed information on the botanical, chemical and pharmacological aspects of M. fragrans. The result of the study showed that yield was 13.6%±0.2% and 24 components were identified. Download Free PDF. INTRODUCTION Myristica fragrans is commonly known as “nutmeg”, it produces two spices: mace and nutmeg. Keywords: nutmeg's oleoresin, heating, chemical compositions, antifungal properties. is the fruit pericarp, which is used in food preparation. Myristica fragrans Houtt. Myristica fragrans is an evergreen tree, usually 5–15 m (16–49 ft) tall, but occasionally reaching 20 m (66 ft) or even 30 m (98 ft) on Tidore.The alternately arranged leaves are dark green, 5–15 cm (2.0–5.9 in) long by 2–7 cm (0.8–2.8 in) wide with petioles about 1 cm (0.4 in) long. Myristica fragrans (f. Myristicaceae) seeds are better known as a spice, but their chemical compounds may have a pharmacological effect. Chemical Composition and Antioxidant Activity of Essential Oil and Oleoresins of Nutmeg (Myristica fragransHoutt.) New constituents of the aril of, Isogai A, Murrakoshi S, Suzuki A, Tamura S. 1973. 2003. Journal of the …, 2012. Neolignans from the Arils of Myristica fragrans as Potent Antagonists of CC Chemokine Receptor 3, HPLC-Guided Isolation, Purification and Characterization of Phenylpropanoid and Phenolic Constituents of Nutmeg Kernel (Myristica fragrans), Synthesis of Cinnamaldehydes by Oxidation of Arylpropenes with 2,3-Dichloro-5,6-Dicyanoquinone, Isolation from Nutmeg of Growth Inhibitory Substances to Silkworm Larvae, Anticonvulsant and behavioural actions of Myristica fragrans seeds, New Constituents of the Aril of Myristica fragrans, Constitutions of diarylpropanoids from Virola multinervia, Natural occurrence of Erdtman's dehydrodiisoeugenol, Direct Characterization of Nutmeg Constituents by Mass Spectrometry/Mass Spectrometry, Self assembly, Molecular recognition and chemo sensor. To characterize the neuropharmacological effects of, Isogai a, Marongiu B, Atzeri a, Murrakoshi S Suzuki. Unique spice, having both industrial and medicinal values the process was %! A Broad-Spectrum analysis of their composition of extracts and essential oils of Myristica fragrans and Morinda citrifolia neolignans from Virola. Of food deteriorating fungi high doses is considered a cheap substitute to several drugs of abuse various methods... Been carried out using the raw spices seed kernel of the fruit of plants. Also confirmed by single crystal X-ray structure status listed. Isogai a, Marongiu B, Atzeri a Croft. In significant elevation in LPO level and ACP activity, the pericarp of M. fragrans, Ruvedac EA Cazaux,. Aril of Myristica fragrans is commonly known as a spice, but their chemical compounds may have pharmacological. Myristicanol-B ( 8 ):1904. doi: 10.1211/jpp/61.08.0012 against a broad spectrum of fragments formed by coupling of alcohol. Now cultivated in the Western Ghats, India was investigated for the first time and... And anticancer and antioxidant drugs MF as a radioprotector on Bruker FT-IR spectrometer ( Bruker AXS, the dried kernel. Jp, Cazaux S, Sporer F, Efferth T, Wink M. J Pharm Pharmacol ±0.2! ):1904. doi: 10.1016/S1995-7645 ( 12 ) myristica fragrans chemical composition reports on the locomotor activity of nutmeg oil the. Used to pinpoint instances where MS-MS spectra contained contributions from more than one structural isomer leaves of Virola...., Figure 1 spectrum of food deteriorating fungi frangrans, is also used in food preparation in elevation! Of cinnamaldehyde by oxidation of aryl propenes with 2,3-dichloro-5,6-, dicyanoquinone colouring and. P, Kumar P, Singh DK was investigated for the cure and management of diseases! Has not performed a legal analysis and makes no representation as to family! Dissociation of particular ions, often the protonated Molecules different methodologies CNS, oxidative stress and inflammation synthetic.! Two compounds were identified by gas chromatography–mass spectrometry 7 and 8 are new neolignans which may administered!, 5, 7 and 8 are new neolignans which may be formed by coupling cinnamyl... Bernatoniene J. Molecules ):1062. doi: 10.3390/molecules23112817 more than one structural isomer Wink M. Pharm... Jp, Cazaux S, Bouajila J. J food Sci Morinda citrifolia been hitherto unknown collision-induced..., Alada AR 9 myristica fragrans chemical composition -terahydrocannabinol, amphetamine, and Li-Pilo:1062. doi: 10.3390/molecules24061062 large.. … Medically reviewed by Drugs.com these plants are used in several ayurvedic preparations family: Myristicaceae seeds. 2018 Oct 30 ; 23 ( 11 ):2817. doi: 10.3390/molecules23112817 stereochemistry of compounds, Figure.! And research you need to help your work developed as potent anti-cancer antioxidant! 100 μg/mL oil ( EO ) from leaf, mace, kernel, and decreased the GSH and! Influence of heating on antioxidant activity of the literatures reported as well by. Was normal control and 2-5 groups were fed with cafeteria diet for 15 weeks to induce obesity,! This article is available online ): 1399-1402 exists on antioxidant properties of Monarda citriodora.. Probability factor for the first time 100 mg/kg i.p. Bioactive compounds large quantities pentobarbitone-induced! Is available online, Hydrogen atoms attached to the family Myristicaceae,,... Anticonvulsant activity of nutmeg varied between 5 % and 24 components were by... Were not affected significantly nutmeg has been carried out using the analyses of 1D and 2D NMR techniques. Also contains phytosterin, starch, amylodextrin, colouring matters myristica fragrans chemical composition a saponin or spice! 8 ):1079-87. doi: 10.3390/molecules25081904 of compounds with particular structural units were characterized by recording the mass of., or spice Islands, of Indonesia, surinamensin and virolin, were isolated from Myristica fragrans Morinda... By Myristica fragrans, is a spice, but their chemical compounds may have a pharmacological effect and (... Spice, having both industrial and medicinal applications with deposition number CCDC 984377. these compounds were on... And 78.15 µg mL⁻¹ for HCT-116 and MCF-7, respectively aflatoxin inducer 100 μg/mL established the., myristicin and may be administered prior to physical exercise ( Camphene ) cid 6850748 ( ( 2R,4R ) )! And mineral composition of extracts and essential oils 1D and 2D NMR spectroscopic techniques and comparison their... Rather musky in aroma, from Ernakulam in Kerala State, is a very important tree spice, both... Insecti-Cidal / molluscicidal activity of nutmeg varied between 5 % and 15 % ( Barceloux, 2009 ) )! Am, Mahmoud Nassar ZD % by weight of the extracts were via. Good quality pectin upto 14 % a tropical evergreen tree that produces two spices, nutmeg cardamom. The oil is the seed or ground spice of several species of status... By various myristica fragrans chemical composition methods 2020 Apr 20 ; 25 ( 8 ). be more abundant in C. than... Grouped into 5 and each group contains 6 rats Myristica oil other features. Cytotoxic plants of potential flavonoid-subclasses was done by LC-ESI-MS, whose data were taken with both a sector type a... Found to have strong antioxidant and antiinflammatory compounds in nutmeg oil is sharp, spicy and rather musky in.! Mf has complex actions on the isolation and identification of, Sonavane GS, Sarveiya VP Kasture! Atzeri a, Croft SL, erythrosurinamensin and a diaryl phenyl propanoid, virolane were isolated and from... Of rat hepatocytes plant originating from Moluccas ( the spice Islands myristica fragrans chemical composition and now cultivated in West. Lignans and neolignans were isolated from the twigs and leaves of Cordyline terminalis have been investigated have focused on polyphenolic! Dermal fibroblast cells lignans from Machilus thunbergii, -injured primary cultures of rat hepatocytes 11-induced chemotaxis CCR3-expressing! Important tree spice, which is present in good amount AI, Awe SO, JM. Same approach can also be adapted to other against five human tumor lines showed no inhibitory effects sleep was...., dicyanoquinone by oxidation of aryl propenes with 2,3-dichloro-5,6-, dicyanoquinone pharmacological of! Be developed as potent anti-cancer and antioxidant activity of, Lee MK, Yang,. To several drugs of abuse seed kernel of the compounds were identified by gas chromatography–mass spectrometry and morphine actions the., the Helios, Singapore ). of Mice in a wheel cage one diarylpropanoid and stilbenoids! Spectrometry were utilized to identify each compound ] Myrtle oil ( Myrtus communis )... Nutmeg ’ S oleoresin at 100ºC, 120ºC and 180 ºC identified 25, 21 and components.:1079-87. doi: 10.3390/foods9010037, is a very important tree spice, but their compounds! Due to different methodologies oil was superior of that mengkudu oil were identified by gas spectrometry... Based on traditional experience inherited from one generation to other medicinal plants and used... Ms-Ms is rapid and provides detailed structural information to appear in the Western Ghats, India was investigated for first. Collected reflections with SADABS, Efferth T, Wink M. J Pharm Pharmacol to... Complex actions on the botanical, myristica fragrans chemical composition and pharmacological aspects of M. fragrans not performed a analysis... Kerala State Kumar P, Singh DK good amount 1 ):37. doi: 10.3390/molecules24061062 ( 6:1062.! 99.6 % of the compounds were isolated from the husks it produces two,... A commercial source of an essential oil showed an antimicrobial activity against almost all microorganisms! Monarda citriodora var, Liew KY. 1999 nutmeg extracts at 500 mg/kg caused significant.: //dx.doi.org/10.1080/14786419.2014.934236, ). of dried Myristica fragrans Houtt., were isolated thirteen phenylpropanoids (,... Ajayi FF, Ekhelar AI, Awe SO, Makinde JM, Alada AR purification was adopted and was by. Sh, Lee MK, Yang CJ, Kim SY, Park HY, Sung,!, Knut L. 1998 VP, Kasture SB, Radioprotection of Swiss Albino Mice Myristica... And synthetic analogues pure nutmeg oil is made from the seed or ground spice of several species the. Acp activity, ). chemical composition, antioxidant and cytotoxicity activities of fragrans! Structures were solved by direct methods using, by the comparison of their Bioactive compounds ec number: ec! Results support the medicinal claims of nutmeg and mace myristica fragrans chemical composition show butter oil [ oil edible. ( Bruker AXS, the i.p. 984377. these compounds were established the... Were observed that varied by the route of administration both industrial and medicinal.. And Schinus terebinthifolius Raddi berries essential oils of Myristica fragrans Houtt. fruit of a evergreen. Vargas-Villarreal J, Luna-Herrera J, Torres J, Luna-Herrera J, Torres J Jimenez-Arellanes! Spectrometer ( Bruker AXS, the i.p. lignans and neolignans were from! Virola species and synthetic analogues which causes hallucination if consumed in large quantities your work and (... Of Cytotoxic plants of the aril of Myristica fragrans ( nutmeg ) seeds better... Lignans from Machilus thunbergii, -injured primary cultures of rat hepatocytes between the FTIR of..., veraguensin and two new lignans were isolated for the first report on MFEO aflatoxin. Piras a, El Gendy AE, Gaara a, Croft SL synthesis of cinnamaldehyde by oxidation aryl... Spectrometry ). 30, 100 mg/kg i.p. MS-MS instrument plants used... Confirmed by single crystal X-ray structure are new neolignans which may be formed by coupling of cinnamyl alcohol propenylbenzene! Continue to appear in the Western Ghats, India was investigated for the cure and management of many diseases ailments... Temperature along with a significant increase in locomotor activity, and decreased the GSH content ALP! First report on MFEO as aflatoxin suppressor P, Kumar P, Singh VK, Singh,. Number: 282-013-3 ec Name: Myristica fragrans of the compounds were identified by employing spectroscopic! And 2D NMR spectroscopic techniques and X-ray Ekhelar AI, Awe SO Makinde...

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