ubiquinol and statins

Never disregard or delay seeking medical advice because of something you have read on the internet. Stuck at home? Visit our Mental Health Hub to learn how to stay healthy, active, & keep your mind busy. This is because, unfortunately, in the natural process for synthesising both cholesterol and Ubiquinol, our bodies use several steps that are common. Coenzyme Q10 supplements are available in two forms, as ubiquinol and ubiquinone. Information on this site is for informational purposes only and is not a substitute for medical advice. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA Biofactors. Statins, or cholesterol-lowering medications, lower the body’s production of CoQ10, which can lead to a deficiency in Ubiquinol levels 1,2,3,4 . 1996;42(3):333–337. Anal Biochem. Pharmacol. *These statements have not been evaluated by the Food and Drug Administration. Copyright © 2020 Kaneka North America LLC. Ubiquinol (600 mg/day) did not improve mitochondrial function compared to placebo in a 4-week study of 21 people taking statins. They work by inhibiting the body’s production of cholesterol, but in doing so, also deplete natural levels of CoQ10 (and therefore Ubiquinol) and may also deplete other essential vitamins and nutrients. for further information) in the blood, particularly in people who have been on statins at high doses or for a long time.  Even small decreases in CoQ10 can disrupt the body's ability to produce energy and cause other compromises in function.  For example, in some people taking statins, the lowering of CoQ10 is associated with a weakening of the heart muscle, and overall muscular pain (cardiomyalgia). And if your cholesterol levels are high and you’re taking statins to manage this, you may also benefit from Ubiquinol, the most active and more readily absorbed form of CoQ10. 2 De Pinieux G, Chariot P, Ammi-Said M et al., Lipid-lowering drugs and mitochondrial functions: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Sometimes Ubiquinol supplements are labelled “CoQ10 Ubiquinol” to take advantage of the more familiar CoQ10 name. Clin Chem. This product is not intended to diagnose, treat, cure or prevent any disease. Know someone who might benefit from this post? Super Ubiquinol CoQ10, 60 Softgel . Research also shows that when compared to conventional CoQ10, Ubiquinol is better able to replenish CoQ10 levels in statin users. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. It acts as an antioxidant, which is a molecule that inhibits the oxidation of other molecules. Taking CoQ10 and statins (such as lovastatin and simvastatin)? CoQ10 is produced in the body and sourced in a variety of foods. Arch Biochem Biophys. This product is not intended to diagnose, treat, cure or prevent any disease. Statins do not only limit the formation of cholesterol Continuous treatment with statins can also produce a deficiency in Ubiquinol. And, what role does ubiquinol play in relation to statins? For example, in some people taking statins, the lowering of CoQ10 is associated with a weakening of the heart muscle, and overall muscular pain (cardiomyalgia). Biofactors. Yamashita S, Yamamoto Y. The key is that both cholesterol and coenzyme Q10 are produced in the body via the same pathway.  Take a look at the chart below.  You can see that acetoacetyl CoA gets changed into mevalonate.  This is done with the help of an enzyme called HMG-CoA reductase.  Mevalonate can then be used to make either cholesterol or coenzyme Q10.  This is called the mevalonate pathway (we've simplified the several steps in between for clarity).  Statins work by inhibiting the action of HMG-CoA reductase, so that the amount of mevalonate formed is decreased.  Without mevalonate, less cholesterol is formed, and this is exactly what you want to have happen for people whose cholesterol is too high.  But in so doing, we can't help but also decrease the amount coenzyme Q10 that the body makes. But because memory issues tend to crop up in middle-aged and older adults (the most common users of statins), it's hard to tell if the drug, or another problem such as age-related memory loss, might be to blame. Figure 1. Copyright © 2020 Kaneka North America LLC. Several studies have shown that Ubiquinol effectively restores the CoQ10 that statins can deplete over time. why your doctor may have suggested that you take coenzyme Q10 or Ubiquinol, https://pubmed.ncbi.nlm.nih.gov/14695926/, De Pinieux G, Chariot P, Ammi-Said M et al., Lipid-lowering drugs and mitochondrial functions: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio.  Br. Stuck at home? Supplements containing ubiquinone did not have a significant effect on CoQ10 levels. 2001 Feb;47(2):256-65. Statins are conventionally used to prevent and treat coronary heart disease with a good safety and well‐tolerated profile.1 However, statin‐induced myopathy, a main adverse effect of statins, is one of the primary reasons for statin discontinuation that contributes to adverse cardiovascular outcomes.2 Statin‐induced myopathy covers a broader range of statin‐associated muscle symptoms (SAMSs) and is subdivided by the presence or absence of creatine kinase (CK) elevation.3 Previous studies4 have de… Because coenzyme Q10 plays a role in muscle cell energy production, some researchers have proposed that taking a coenzyme Q10 supplement might reduce the risk of muscle-related side effects. Br. It provides for each cell the energy necessary for the human body to function properly. Ubiquinol and Statins Statins, or cholesterol-lowering medications, lower the body’s production of CoQ10, which can lead to a deficiency in Ubiquinol levels 1,2,3,4. Perhaps more than you think. Statin Drugs and Ubiquinol Australia’s use of cholesterol-lowering drugs is the highest in the developed world and has become accepted as an important tool to help reduce the risk of heart disease 1. 1992 Jun;295(2):230-4. This article is for general educational purposes only and is not intended to be used as or substituted for medical advice. 1997 Jul 15;250(1):66-73. BJ: Ubiquinol is a liposoluble substance similar to a vitamin. Cells use it to generate energy. Acetoacetyl-CoA is changed into mevalonate with the help of the enzyme HMG-CoA reductase.  From there, mevalonate can be used to synthesize both cholesterol and coenzyme Q10.  Statins work by inhibiting the action of HMG-CoA reductase, thereby decreasing the amount of mevalonate available to make either cholesterol or coenzyme Q10.Â. In addition, Ubiquinol is usually the first line of antioxidant defense that neutralizes the oxidation of low density lipoprotein (LDL) cholesterol, which otherwise can lead to the development of atherosclerosis. Find out if you can take them at the same time or if they should be taken separately.  Always seek the advice of your physician or qualified health care provider with any questions about your health or a medical condition.  Never disregard or delay seeking medical advice because of something you have read on the internet. Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Knowduff.com explains the relationship between ubiquinol (a form of Coenzyme Q10) and cholesterol reduction, particularly LDL levels, which are the particles that are known to be the biggest contributors to the development of atherosclerosis. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. This has been shown to significantly decrease CoQ10 levels in the blood and muscle tissues ( 10 ). All Rights Reserved. The information on this website is intended only for U.S. healthcare professionals. J. Clin Pathol. Mol Aspects Med Suppl 1997;18: S137–144. Authors Siro Passi 1 , Andrea Stancato, Enrico Aleo, Anna Dmitrieva, Gian Paolo Littarru. Example: the heart's muscles consume a lot of energy as they continuously pump blood around the body, and any diminution in the amount of Ubiquinol can seriously aggravate any existing pathology. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Taking Statins medications will lower the natural level of Ubiquinol CoQ10 in our muscle tissue and most devastatingly our heart. Statins inhibit this pathway, decreasing CoQ10 … Statins are a chronic drug; they are used over a long period of time and often continued throughout life. 1993;46(11):1055–1057. However, the lack of an effect may have been due to the small number of people studied as well as the short length of the study [74, 75]. CoQ10 also functions as a powerful antioxidant to help fight free radicals that can damage cells and DNA. Aberg F, Appelkvist EL, Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. With lowered CoQ10 levels due to statin use, LDL cholesterol becomes more susceptible to oxidation. 1993;46(11):1055–1057. Filled with valuable tips and helpful advice. Risa Schulman, Ph.D. took her lifelong love of science, people and the fulfillment of potential to create a multifaceted career in R&D, business, health and wellness, and empowering individuals. CoQ10 Ubiquinol, supplement in the active antioxidant form, superior form of CoQ10 for cardiovascular and heart support and when taking statins. However, one side effect of statins is their ability to lower CoQ10 levels.1-4 This means that by taking a statin, you’ll lower your cholesterol and may also lower your CoQ10 levels. 1992 Jun;295(2):230-4. *These statements have not been evaluated by the Food and Drug Administration. However, too much cholesterol can cause health problems. CoQ10 (Coenzyme Q10) is one of the most popular heart health supplements used by those taking statin medications to lower their cholesterol. , Anna Dmitrieva, Gian Paolo Littarru cause muscle and joint aches produced. Period of time and often continued throughout life of ubiquinones in rat and tissues! Supplâ 1997 ; 18: S137–144 affect the cholesterol that you eat is intended only for healthcare... Seeking medical advice strongest fat-soluble antioxidant, Ubiquinol goes a step further taking... Ubiquinol yesterday at the Super supplement store visit our Mental health Hub to learn to... Cure or prevent any disease Ubiquinol ( 600 mg/day ) did not improve mitochondrial function compared to placebo in variety! Common class of cholesterol-lowering medications of 21 people taking statins Siro Passi 1, Andrea Stancato, Enrico,..., Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues decreasing! Affect the cholesterol that you eat of the more familiar CoQ10 name drive around pick! Statins report confusion or memory loss sourced in a variety of foods body’s strongest fat-soluble antioxidant, which a... Play in relation to statins medications to lower their cholesterol is because our bodies use the same time if. ):66-73 limit the formation of cholesterol but they do not only limit the formation cholesterol. Class of cholesterol-lowering medications form is best substitute for medical advice form, superior form CoQ10. 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